A study reveals widespread and unnecessary use of ICSI, in Australia, with questionable benefits for couples without severe male infertility. A/Prof Alex Polyakov’s research suggests roughly 30% of couples would benefit from ICSI for male-factor infertility, contrasting conventional IVF’s effectiveness for those with normal semen analysis. Polyakov highlights the natural sperm selection process in conventional IVF versus lab-selected sperm in ICSI. The study prompts calls for judicious use of ICSI to avoid financial burden and potential health risks.